Robert S. and Sylvia K. Reitman Family Foundation Distinguished Professor of Cardiovascular Innovation; Professor of Medicine and Biochemistry; Founding Director of the Institute for Transformative Molecular Medicine at Case Western Reserve University School of Medicine; and Co-founder and President of the Harrington Discovery Institute at University Hospitals Health System.
Jonathan S. Stamler, M.D. is an internationally acclaimed physician-scientist known for the discovery of protein S-nitrosylation, a global post-translational modification of proteins that is widely involved in both physiology and disease, and for a track record of innovation and entrepreneurship as a founder of institutes, biotechnology companies, medical societies, innovation platforms and impact investment funds. He has co-authored over 300 original manuscripts and 125 patents/patent applications and co-founded 9 biotechnology companies. His work has been covered in numerous lay publications, including the front page and science sections of the New York Times, as well as Time Magazine and The Economist, in books on the history of science and on luck, and in works on outlier innovators.
Jonathan Stamler discovered protein S-nitrosylation (binding of nitric oxide to Cys residues in proteins), which controls cellular function from bacteria to humans, and plays important roles in disease, from heart failure to Alzheimer’s and cancer. All main classes of proteins can be modified by S-nitrosylation, and Stamler has revealed enzymatic regulation of S-nitrosylation, and offered novel insights into mammalian physiology, including functions of the heart, skeletal muscle, and airways. His notable discovery that red blood cells dilate blood vessels revealed the essential role of nitric oxide carried by hemoglobin cysteine residues in oxygenating tissues, re-defining the respiratory cycle as a three- (not two-) gas system—O2/NO/CO2. Dr. Stamler recently discovered trans-kingdom nitric oxide signaling through which microbiome bacteria broadly modify host proteins to control animal physiology and development, and he identified how the drug nitroglycerin works. His discoveries have thus changed the understanding of signaling by gaseous messengers, reshaped nitric oxide/redox biology, and broadly impacted the biological sciences.
Dr. Stamler received his bachelor’s and medical degrees from Brandeis and Mount Sinai School of Medicine, and completed his internship, residency and fellowships in cardiovascular and pulmonary medicine at Harvard Medical School and Brigham and Women’s Hospital. He spent sixteen years at Duke University, including as an investigator of the Howard Hughes Medical Institute, before joining Case Western Reserve University and University Hospitals. He has received many honors, including from the Ewing Marion Kauffman Foundation for being among the “Top Innovators in America” and by the American Heart Association for being a “Distinguished Scientist.”
To learn more about Jonathan Stamler's lab, click here.