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December 16, 2025

A Triple-Action PROTAC for Wild-Type p53 Cancer Therapy

Despite the central role of p53 suppression in cancer pathogenesis, the promise of therapeutic p53 reactivation remains unrealized, with targeted and combination chemotherapies limited by efficacy, toxicity, and delivery. Continue Reading

November 20, 2025

Oxford-Harrington Rare Disease Centre Announces 2025 Scholars Advancing Promising Treatments

Ten scientists selected for second annual award to pursue innovations in gene, RNA, small molecule and cell therapies to treat rare and ultra-rare diseases Continue Reading

November 14, 2025

Lifelong Drugs for Autoimmune Diseases Don’t Work Well. Now Scientists are Trying Something New.

Scientists are trying a revolutionary new approach to treat rheumatoid arthritis, multiple sclerosis, lupus and other devastating autoimmune diseases — by reprogramming patients’ out-of-whack immune systems. Continue Reading

November 13, 2025

Support from Harrington Discovery Institute at University Hospitals Helped Advance Heart Attack Drug into Clinical Trials

Positive results at AHA Scientific Sessions, published in NEJM Evidence Continue Reading

October 15, 2025

Harrington Discovery Institute at University Hospitals and Case Western Reserve School of Medicine Open Call for 2026 Harrington-MSTP Scholar Award

Grant award provides MD/PhD candidates with funding and expertise to translate promising scientific discoveries into medicines Continue Reading

September 10, 2025

Oxford-Harrington Rare Disease Centre Announces David Cameron, Chair of its Advisory Council, as a Guest Speaker at Morgan Stanley Exchange 2025

In ‘A Conversation on Courage,’ Lord Cameron and Morgan Stanley’s Andy Saperstein discussed philanthropy as a catalyst for rare disease innovation Continue Reading

July 20, 2025

Targeting an Enzyme Could Rewire Cancer Cells to Suppress Growth by up to 77% for Melanoma and Colorectal Tumors

Published in Good News NetworkEleven years of cancer research has proven fruitful for a scientist at Johns Hopkins who uncovered a new tumor-suppressive response that could lead to novel therapies targeting hard-to-treat cancers.The new study, funded in part by the National Institutes of Health and the National Cancer... Continue Reading

July 09, 2025

Breakthrough Treatment Helps Child Walk Again After Rare Brain Disease Diagnosis

Experimental Compound Offers Potential Treatment for Rare, Often Fatal, Childhood Disease Continue Reading

July 09, 2025

Coenzyme Q Headgroup Intermediates Can Ameliorate a Mitochondrial Encephalopathy

Decreased brain levels of coenzyme Q10 (CoQ10), an endogenously synthesized lipophilic antioxidant, underpin encephalopathy in primary CoQ10 deficiencies and are associated with common neurodegenerative diseases and the ageing process. Continue Reading

June 24, 2025

Nominations Open for 13th Annual International Harrington Prize for Innovation in Medicine

Harrington Discovery Institute and the American Society for Clinical Investigation seek nominations to recognize an outstanding achievement by a physician-scientist Continue Reading

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