University Hospitals Recruits Top Neuroscientist to Join Harrington Discovery Institute
CLEVELAND – University Hospitals has recruited Andrew Pieper, MD, PhD, one of the nation’s leading physician-scientists in the field of neuropsychiatric disorders. Dr. Pieper joins the Harrington Discovery Institute – part of The Harrington Project for Discovery & Development – at UH. Dr. Pieper also will be a faculty member of the Departments of Psychiatry at UH and the Louis Stokes... Continue Reading
October 21, 2021
Researchers Home in on Biochemical Link Between Brain Injury, Alzheimer's Disease
Researchers have discovered an approach that could prevent nerve cells in the brain from deteriorating after a traumatic brain injury (TBI).A research team including scientists with the Geriatric Research Education and Clinical Center at the Louis Stokes Cleveland VA Medical Center identified the approach for preventing nerve cell degeneration by exploring the connection between TBI and... Continue Reading
September 10, 2024
New Study Shows that Chronic Neurodegeneration can be Prevented after Traumatic Brain Injury
CLEVELAND – Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with chronic neurodegeneration and related impairments due to TBI. In addition to cognitive and mental health impairment, chronic neurodegeneration may also contribute to why TBI increases the risk of age-related neurodegenerative diseases... Continue Reading
Cell Reports Medicine PublicationProgression of acute traumatic brain injury (TBI) into chronic neurodegeneration is a major health problem with no protective treatments. Here, we report that acutely elevated mitochondrial fission after TBI in mice triggers chronic neurodegeneration persisting 17 months later, equivalent to many human decades. We show that increased mitochondrial fission after... Continue Reading
May 21, 2025
Inhibiting 15-PGDH blocks blood–brain barrier deterioration and protects mice from Alzheimer’s disease and traumatic brain injury
Published in Proceedings of the National Academy of Sciences (PNAS)Alzheimer’s disease (AD) and traumatic brain injury (TBI) are currently untreatable neurodegenerative disorders afflicting millions of people worldwide. These conditions are pathologically related, and TBI is one of the greatest risk factors for AD. Although blood–brain barrier (BBB) disruption drives progression of both AD... Continue Reading
