Calls Now Open

2024 ADDF-Harrington + 2025 Harrington Scholar-Innovator Programs

You've just added:


Toren Finkel, MD, PhD

Toren Finkel, MD, PhD

University of Pittsburgh

Disease Areas

Respiratory, Rare/Orphan


A Small Molecule NAMPT Activator to Reverse Age-Dependent Decline in NAD+

Scholar Profile

2021 Harrington Scholar-Innovator

Good health is the wish traditionally conveyed by toasts in cultures around the world. Dr. Finkel, however, is doing more than simply raising a glass and wishing; he is conducting research into aging with the goal of helping humans remain healthier longer.

Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme found in every cell of the human body, and is involved in hundreds of metabolic processes. Aging is associated with a decline in tissue NAD+ levels, and this decline has been linked to various age-related diseases.

Dr. Finkel and his colleagues are researching the effects of restoring NAD+ levels with a small molecule that augments the activity of NAMPT, the enzyme that controls NAD+ levels. Boosting or restoring NAD+ levels could represent a potential preventive therapy for a wide range of age-related diseases.

Dr. Finkel and his team developed an innovative screening platform to identify— from an initial library of more than 100,000 compounds—a set of small molecules that directly bind to NAMPT. They further determined that a subset of these binding molecules can potently augment NAMPT activity. This approach thereby represents a novel overall strategy to modulate NAD+ levels.

Dr. Finkel is quick to point out that this research is not a quest for the mythical Fountain of Youth.

“We're not really trying to extend lifespan,” Dr. Finkel says. “We're trying to expand ‘health span,' which is basically the time that individuals live free of diseases. The goal is to identify targets that link aging and disease and reduce the diseases and morbidities individuals face in their last few decades.”

Unlocking the Secret to a Healthier Aging: Dr. Tor

Join us on a journey to combat aging's impact on human health with Dr. Toren Finkel, a 2021 Harrington Scholar-Innovator from the University of Pittsburgh. Dr. Finkel's groundbreaking research focuses on Nicotinamide adenine dinucleotide (NAD+), a coenzyme vital to our body's metabolic processes. Aging is often accompanied by declining NAD+ levels, linked to various age-related diseases. Dr. Finkel's innovative approach involves a small molecule that augments NAMPT, the enzyme controlling NAD+ levels, offering a potential preventive therapy for age-related ailments. Dr. Finkel's team identified compounds that boost NAMPT activity from a vast library of molecules. Their goal is not to extend lifespan but to extend "health span," enabling individuals to enjoy more disease-free years.

We have updated our Online Services Terms of Use and Privacy Policy. See our Cookies Notice for information concerning our use of cookies and similar technologies. By using this website or clicking “I ACCEPT”, you consent to our Online Services Terms of Use.