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June 04, 2025

David Cameron: DNA test all sick children to build register

The former prime minister has called for children admitted to paediatric care to undergo genome sequencing as part of a drive to cure 40 rare diseases Continue Reading

May 21, 2025

Inhibiting 15-PGDH blocks blood–brain barrier deterioration and protects mice from Alzheimer’s disease and traumatic brain injury

Alzheimer’s disease (AD) and traumatic brain injury (TBI) are currently untreatable neurodegenerative disorders afflicting millions of people worldwide. These conditions are pathologically related, and TBI is one of the greatest risk factors for AD. Continue Reading

January 27, 2025

Baby with spina bifida has promising future after fetal surgery with stem cells

At 18 weeks pregnant, Lindsey learned her baby had severe spina bifida. She joined UC Davis’s groundbreaking CuRe Trial combining fetal surgery and stem cells. Over a year later, her son is thriving. Continue Reading

December 11, 2024

Could Psoriasis Treatment Be This Simple?

An off-the-shelf drug shows promise as a low-cost topical treatment for psoriasis. New findings highlight benzamil’s potential to reduce inflammation and skin cell overgrowth without steroids or immune suppression. Continue Reading

September 17, 2024

Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury

Progression of acute TBI to chronic neurodegeneration is a major health problem with no protective treatments. Time sensitive inhibition of acutely elevated mitochondrial fission may present a way to protect patients from chronic neurodegeneration. Continue Reading

July 16, 2024

Case Western Reserve University receives $1.5M grant from Foundation Fighting Blindness to test possible new treatment for inherited retinal disease

There’s only one U.S. Food and Drug Administration-approved therapy for an inherited retinal disease, and dozens of retinitis pigmentosa (RP) genes for which no therapy is available. Continue Reading

March 25, 2024

Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation

Nature Chemical Biology, published March 25, 2024 Continue Reading

March 13, 2024

Going atom-by-atom, Stanford researchers craft a new precision drug for fighting COVID-19

The rapidly evolving SARS-CoV-2 virus threatens the progress made in curbing the COVID-19 pandemic. A promising novel drug candidate, designed at the atomic level, could help doctors halt the rise of lethal new drug resistant variants. Continue Reading

January 16, 2024

Novel inhaled TB vaccine

The Jenner Institute is conducting a new study, using BCG, the current licensed vaccine against tuberculosis. Continue Reading

December 21, 2023

Allyx Therapeutics Lead Compound ALX-001 is Safe and Tolerable at Doses, Achieving Full Brain Target Engagement in Healthy Older Adults

The study showed that all doses of ALX-001 were well tolerated, up to and including levels high enough to achieve full brain target engagement, supporting the company’s plans to continue clinical development for the treatment of Alzheimer’s disease. Continue Reading

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