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January 18, 2022

Harrington Discovery Institute Advances COVID-19 Treatments

Four Medicines in Clinical Trials and More in the Pipeline When it came to vaccines being trialed to prevent COVID-19, University Hospitals was already at the national forefront of innovations advancing COVID-19 treatments in mid-2020. Now four Scholars at Harrington Discovery Institute at University Hospitals might well be... Continue Reading

January 01, 2022

Harrington Discovery Institute Origin Story

Harrington Discovery Institute advances scientific breakthroughs, accelerates drug development, and impacts the standard of care. We cure diseases, together. In 2012, a $50 million transformative gift from Ron and Nancy Harrington and their children Jill, Ron, and Lydia Harrington, made possible the vision of Dr. Jonathan... Continue Reading

December 09, 2021

LSU And Takeda Partner To Advance Harrington Scholar’s Therapy For Rare Neurological Disorders

New Orleans, LA – LSU Health New Orleans entered into an exclusive option and license agreement with Takeda Pharmaceutical Company Limited (“Takeda”) granting Takeda the exclusive right to develop further a technology invented at LSU Health New Orleans with the aim to discover potential therapeutics to treat... Continue Reading

November 16, 2021

WKYC TV Interview: Science Helps to Develop New Weapons in Fight Against COVID-19

As the COVID-19 pandemic continues on, scientists around the world are also developing new and creative ways to fight the virus. CLEVELAND — In 2020, during the height of the COVID-19 Pandemic, Harrington Discovery Institute at University Hospitals put out a call to scientists around the world: Send us your ideas to... Continue Reading

October 21, 2021

Researchers Home in on Biochemical Link Between Brain Injury, Alzheimer's Disease

Researchers have discovered an approach that could prevent nerve cells in the brain from deteriorating after a traumatic brain injury (TBI). A research team including scientists with the Geriatric Research Education and Clinical Center at the Louis Stokes Cleveland VA Medical Center identified the approach for preventing nerve... Continue Reading

October 18, 2021

Researchers Awarded $12 Million to Pursue Personalized Therapies for Severe Asthma

INDIANAPOLIS— A group of researchers led by Indiana University School of Medicine’s Benjamin Gaston, MD, has been awarded a research program project grant (P01) from the National Heart, Lung and Blood Institute. The award amounts to just over $12 million over the next five years and will fund the development of... Continue Reading

October 11, 2021

Tackling Dystonia with an Approved Drug

Dystonias are a group of chronic movement–disabling disorders for which highly effective oral medications or disease-modifying therapies are lacking. The availability of an oral drug with disease-modifying potential would transform the current treatment landscape. 2015 Harrington Scholar-Innovator Nicole Calakos, MD, PhD... Continue Reading

October 11, 2021

New Study Finds Therapeutic Treatment Option for Metabolic Syndrome, Obesity

Metabolic syndrome is a cluster of conditions and includes obesity and can be dangerous as it increases the risk for heart disease, stroke, diabetes and other diseases. A Harrington Discovery Institute research team proves successful use of “anti-obesity” drug in pre-clinical animal models. “The last piece of... Continue Reading

October 11, 2021

Small-Molecule Suppression of Calpastatin Degradation Reduces Neuropathology in Models of Huntington’s Disease

Huntington’s Disease (HD) is a fatal neurological disorder caused by a trinucleotide CAG repeat expansion in the N-terminal exon 1 of the huntingtin (Htt) gene. HD manifests as uncontrolled involuntary movements accompanied by progressive motor and cognitive deficits, psychiatric disturbance, and dementia. There is no... Continue Reading

August 19, 2021

Oxford-Harrington Partnership Targets FA as First Priority

Scientists on either side of the Atlantic have teamed up, through the new Oxford-Harrington Rare Disease Centre (OHC), to address unmet needs in rare disease research and deliver “major clinical impact” to patients. And now, the international collaboration between the University of Oxford, in England, and the... Continue Reading